Benzodiazepine derivative are most widely useful as anti fungal, anti inflammatory, anti depressive, anti anxiety and sedative and hypnotics. Due to wide pharmacological action we have selected benzodiazepines and prepared 2, 4-di substituted benzodiazepines and we evaluated the different substituted derivatives by IR, NMR, and MASS spectroscopic studies. The in-vivo anti inflammatory, and in-vitro anti oxidant activities were performed and the compound (1a-1e) showing good anti inflammatory activity and where as compound (1b-1d) having good activity.
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